美研留学西北大学博士后项目申请介绍

Northwestern University西北大学创立于1851年，一所私立研究型大学，坐落于美国伊利诺伊州东北部城市埃文斯顿，十大联盟创始成员和美国大学协会成员。西北大学由John Evans先生创办于1851年，其主校区位于伊利诺伊州埃文斯顿市郊的密歇根湖湖畔，临近美国第三大城市芝加哥。西北大学医学院坐落在繁华的芝加哥市中心，始建于1926年的医学院大楼Ward Memorial Building是美国第一座学术摩天楼。2022USNews世界排名24。美国西北大学

优势专业

农业及生物工程、人类学、应用经济及商业管理、考古学、建筑、亚洲研究、天文学、生物科学、生物及社会、化学工程、化学、土木及环境工程等。

成绩要求GAp3.54

语言要求托福109

美国西北大学博士后职位招聘

We are looking for two talented and energetic postdoctoral fellows to join Dr.Yan Liu’s laboratory(https://www.feinberg.northwestern.edu/faculty-profiles/az/profile.html?xid=50632)at the Northwestern University Feinberg School of Medicine and Robert H.Lurie Comprehensive Cancer Center,located in Chicago,IL.These positions are fully funded for multiple years.

The Liu laboratory is interested in investigating the molecular mechanisms governing normal and malignant hematopoiesis,with an emphasis on understanding hematopoietic stem cell(HSC)self-renewal and pathogenesis of myeloid malignancies,including clonal hematopoiesis of indeterminate potential(CHIp),myelodysplastic syndromes(MDS)and acute myeloid leukemia(AML).Our long-term goals are to identify novel regulators of HSC self-renewal,understand the molecular mechanisms regulating their function,and develop novel therapeutic strategies to eliminate leukemia stem cells(LSCs)and improve leukemia treatment.

One of the projects in the Liu lab is to determine the role of tumor suppressor p53 in leukemogenesis and treatment.Our studies have led to multiple recent manuscripts,including two manuscripts currently in revision(Vemula et al.,Cancer Discovery,2022;and Chen et al.,Cancer Cell,2022).

1.Liu,Y.,Elf,S.E.,Miyata,Y.,Sashida,G.,Liu,Y.H.,Huang,G.,Di Giandomenico,S.,Lee,J.M.,Deblasio,A.,Menendez,S.,Antipin,J.,Reva,B.,Koff,A.and Nimer,S.D.p53 Regulates Hematopoietic Stem Cell Quiescence.Cell Stem Cell,2009;4(1):37-48.pMCID:pMC2839936.

2.Chen,S.,Gao,R.,Yao,C.,Kobayashi,M.,Liu,S.Z.,Yoder,M.C.,Broxmeyer,H.,Kapur,R.,Boswell,H.S.,Mayo,L.D.,and Liu,Y.Genotoxic stresses promote the clonal expansion of hematopoietic stem cells expressing mutant p53.Leukemia,2018 Mar;32(3):850-854.pMCID:pMC5842141

3.Nabinger,S.,Chen,S.,Yao,C.,Gao,R.,Kobayashi,M.,Vemula,S.,Fahey,A.C.,Wang,C.,Daniels,C.,Boswell,H.S.,Sandusky,G.E.,Mayo,L.D.,Kapur,R.,and Liu,Y.Mutant p53 enhances leukemia-initiating cell self-renewal to promote leukemia development.Leukemia,2019 Jun;33(6):1535-1539.pMID:30675010

4.Chen,S.,Wang,Q.,Yu,H.,Capitano,M.L.,Vemula,S.,Nabinger,S.C.,Gao,R.,Yao,C.,Kobayashi,M.,Geng,Z.,Fahey,A.,Henley,D.,Liu,S.Z.,Wolf,E.R.,Ramdas,B,Cai,Z.,Gao,H.,Luo,N.,Sun,Y.,Wong,T.N.,link,D.C.,Liu,Y.,Boswell,H.S.,Mayo,L.D.,Huang,G,Kapur,R.,Yoder,M.C.,Broxmeyer,H.E.,Gao,Z.,and Liu,Y.Mutant p53 Drives Clonal Hematopoiesis through Modulating Epigenetic pathway.Nature Communications,2019 Dec 11;10(1):5649.doi:10.1038/s41467-019-13542-2.pMID:31827082

The first postdoctoral fellow will determine the impact of mutant p53 proteins on transcription,chromatin accessibility,histone modifications,and 3D chromatin structure in hematopoietic stem cells and leukemia stem cells.

The second postdoctoral fellow will develop novel therapeutic approaches,including small molecule inhibitors and CAR-T therapy,for leukemia patients with p53 mutations.

Successful candidates should be highly motivated and have a recent ph.D.degree with a background in molecular biology,biochemistry,epigenetics,and cancer research.

Applicants should have a strong publication record,creative thinking,effective oral and written communication skills,good team spirit,and a willingness to learn new techniques and approaches.

preference will be given to candidates with strong first-author publications in high-impact peer-reviewed journals.西北大学博士

美研留学西北大学博士后项目申请介绍

WHO WE ARE

We utilize molecular,genetic,immunological,biochemical,and pharmacological approaches as well as unbiased genome wide studies,including RNA-seq,ChIp-seq,ATAC-seq,HiC,whole genome sequencing,CRISpR-Cas9-mediated screening in mammalian cells as well as proteomics studies,to investigate the molecular basis of HSC self-renewal and leukemogenesis.Specific relevant techniques include analysis of DNA,RNA,and proteins,flow cytometry,and experience with murine models and bone marrow samples from patients.

WHERE WE ARE

Our lab is on the fifth floor of the Robert H.Lurie Medical Research Center of Northwestern University in Chicago,IL,which is home to many of the elite biomedical researchers at Northwestern.The Lurie Center and the rest of the Northwestern University Feinberg School of Medicine is located in the heart of Chicago’s Magnificent Mile,blocks away from beautiful Lake Michigan.

Interested candidates should send the following items to Dr.Yan Liu(yan.liu northwestern.edu)

A one-­page cover letter describing areas of research interests and career goals

Curriculum vitae with bibliography

Contact information for 3 references

*Northwestern University is an Equal Opportunity,Affirmative Action Employer of all protected classes,including veterans and individuals with disabilities.Women,racial and ethnic minorities,individuals with disabilities,and veterans are encouraged to apply.Hiring is contingent upon eligibility to work in the United States.

在美国，西北大学是人人皆知的名牌大学。该校创建于十九世纪，至今已有一百多年的历史。西北大学商学院，从1988年至1994年，六年蝉联美国各名牌大学商学院的排名第一位。西北大学位于美国伊利诺伊州的小镇埃文斯通。是莘莘学子们争相报考的学院，它招收严格，只录取最优秀的人才入内深造。西北大学的其他学院和专业也都大名鼎鼎，1998年的诺贝尔奖金获得者中，就有两位是西北大学的人。一位是诺贝尔化学奖的得主之一波普尔，他是西北大学的教授；另一位是诺贝尔医学奖的得主之一、八十二岁的罗伯特·弗奇戈特教授，他是西北大学的毕业生在西北大学获得生物化学博士学位。美国硕士博士

西北大学这所被认为在中西部最为精英的顶级大学，是美国十大名校联盟中唯一的一所私立学校。虽不是常青藤联盟的成员，但比起在美国东部地区同等级的学校来说更专注于教学的实用性。与它邻近的竞争者芝加哥大学，以及除宾大外的所有常青藤学院相比，西北大学的教育更具有职业导向性。

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